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After being absorbed by NK cells and CD8+ T cells, NAA can inhibit the formation of immunological synapses in these cells, leading to immune evasiveness
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Rather than weakening the entire airway mucus layer, inhaled mucolytic-like particles can facilitate penetration by selectively cleaving specific structural components of the mucus 205,206 , preserving the protective function of the mucus layer
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This spatiotemporal heterogeneity reveals the dynamic regulatory nature of hypoxia in tumor immune escape
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