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That follow-up trial, involving 536 obese adults over 24 weeks, failed to meet its primary efficacy endpoint, meaning the fat-loss effect seen at the smaller scale did not hold up in the pivotal study
The MHRA advises patients on all GLP-1s to use contraception while taking GLP-1 medicines (including an additional barrier method for patients starting or increasing tirzepatide who are using oral contraception), as well as for a defined wash-out period afterwards before trying to get pregnant (see Figure 3)
Calcium helps the body function in several ways, including allowing the muscles to move and nerves to communicate messages from the brain to the body
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