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Furthermore, some PBN neurons themselves express GLP1R, raising the possibility of a more direct mechanism linking the action of GLP1R agonists to nausea and vomiting
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Mathew JP, Fontes ML, Tudor IC, Ramsay J, Duke P, Mazer CD, et al
doi: 10.1038/nrdp.2016.14 26 EvenepoelP.ClausD.GeypensB.HieleM.GeboesK.RutgeertsP.et al
In the oxidation of these substrates, until they become medium-chain length, the water addition is catalyzed by an enoyl-CoA hydratase activity, the second oxidation step is catalyzed by an NAD + -dependent long-chain hydroxacyl-CoA dehydrogenase activity [long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) activity], and finally the cleavage into an acyl-CoA and an acetyl-CoA is catalyzed by a thiolase activity
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