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Glutathione represents the most abundant intracellular antioxidant capable of (i) directly interacting with free radical species, (ii) revitalizing other small molecule antioxidants (e.g., vitamins C or E), (iii) maintaining the redox state of protein thiols, and (iv) serving as a cofactor for enzymes of the cellular antioxidant system (Espinosa-Diez et al

Clinicians must balance long-term metabolic benefits against short-term safety concerns

Naito J, Ohashi H, Ohno M et al (2019) Long-term levocarnitine ameliorates left ventricular diastolic as well as systolic dysfunction in hemodialysis patientsmulti-center study

Selenium is also an essential component of other metabolic systems that deal with oxidative stress, such as the thioredoxin system

Master diss., Massey University

But it noted it did not establish a causal relationship