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When riboflavin supplementation is needed, an amount that is five to ten times the daily recommended amount is appropriate ( Reference Said, Ross, Shils, Shike, Ross, Caballero and Cousins 14 )
Additionally, folate deficiency should not be treated in isolation until B12 deficiency has been excluded or treated, as this could worsen neurological damage
Longer-term data and more studies would help reduce my concerns
For routine lab handling, keep the reconstituted solution refrigerated at 2-8C and use it within 30 days
Blood 90 , 33703377 (1997)
Side Effects to Monitor on the Combination While the combination is generally well-tolerated, patients should be aware of a few side effect considerations that are more relevant when taking both medications together
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