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Follow-up Repeat metabolic markers after 4-12 weeks, with closer review during dose escalation or major appetite changes

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However, due to the fact that data regarding long-term application of IGF-1 LR3 is limited, IGF-1 LR3 research study durations tend to last between four to six weeks, followed by an equivalent duration of rest

doi: 10.3389/fendo.2025.1633377 Received 22 May 2025 Accepted 17 September 2025 Published 05 November 2025 Volume 16 - 2025 Edited by Senthilkumar Palaniappan, Karpagam Academy of Higher Education, India Reviewed by Sudhanshu Kumar Bharti, Patna University, India Sanaz Alaee, Shiraz University of Medical Sciences, Iran Updates Copyright 2025 Balkrishna, Rana, Mishra, Agrawal, Rajput, Dhanasekaran, Rana, Arya, Ramu, Upadhayay and Singh

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Moreover, the simulations confirmed that the Cagri P37 had weaker interactions with the ECDs leading to greater uncoupling of the peptide C-terminus from the ECDs (Supplementary Movie 1, Supplementary Tables 4, 5), and parallel increases in the dynamics of the peptide as it engaged with the CTR TM bundle, including F23