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It is to be noted that our cryo-EM analysis also revealed minor structural classes of particles with different conformations besides the ghrelin- and ibutamoren-GHSR-G i complexes with the 2.7 cryo-EM maps (Supplementary Fig
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We propose that dysbiosis promotes ferroptosis in ovarian granulosa cells through disrupted iron homeostasis, diminished production of protective microbial metabolites, and systemic inflammation, collectively contributing to the reproductive and metabolic disturbances in PCOS
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