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This is arguably the most common pathway to clinically significant excess exposure
In both conditions, one would hypothesized that the glucose-dependency of GLP-1 is also lost given the lack of functional K ATP channels in the first, and the concomitant hyperglycemia in the second
The latter used approximately half the maintenance dose of liraglutide that is indicated for weight management
Long-term use at very high doses and interactions with certain medications (particularly nitroglycerin and potentially anticoagulants) warrant provider guidance
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Tirzepatide works differently
