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Breitkreutz, Glutathione and immune function

Single-cell RNA sequencing, spatial transcriptomics, metabolomics, and imaging mass cytometry can distinguish whether therapy alters neuronal stress, astrocyte lactate programs, microglial glycolysis, endothelial angiogenesis, or pericyte detachment

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They demonstrated that human pancreatic tumor and stellate cells activate/process GSAO into its active metabolite and that GT activity positively correlates with GSAO-mediated proliferation arrest of co-cultured endothelial cells ( Figure 3B )

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