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Published reports of GLP-1 agonist overdoses do not document severe complications such as pancreatitis or hypoglycemia (23)

10.1056/NEJMoa1307684 95

What This Means Practically For patients with Type 2 diabetes, these findings have practical implications: First-line treatment recommendation: Major diabetes guidelines now recommend GLP-1 agonists as first-line treatment (alongside or instead of metformin) for patients with established cardiovascular disease

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In sensitive individuals, sustained elevation may cause gynecomastia or reproductive hormone disruption