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PMCID: PMC4021346

GLP-1 medications also have the potential to worsen reflux, increase constipation, and, sometimes, cause diarrhea

Abstract Background: The purpose of this study was to explore how semaglutide, a GLP-1RA, regulates serum metabolism and gut microbiota to improve obesity in mice and whether fecal microbiota transplantation (FMT) can transmit the beneficial effects of semaglutide to recipient mice

1 Engs paper, published in the Journal of Biological Chemistry , noted something strange: exendin-4 shared 53% of its amino acid sequence with a human gut hormone called glucagon-like peptide-1 (GLP-1), which had been characterized just a few years earlier

This connection is rooted in several age-related physiological changes that directly impinge on the core regulatory axes of ferroptosis