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An extreme example of the effects of GCG on lean mass is in individuals with glucagonoma, which is characterised by very high levels of circulating GCG, low levels of amino-acids, and sarcopenia [61, 62]
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The SUSTAIN-6 study demonstrated a 26% reduction in major adverse cardiovascular events, including cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke in high-risk patients with type 2 diabetes
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