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Discussion We previously reported that the glutathione cycle may serve as a reservoir of total neuronal glutamate (16)

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Collectively, these mechanistic insights demonstrate the multifaceted role of gut dysbiosis in shaping brain behaviour and highlight the therapeutic potential of microbiome-targeted interventions, such as probiotics and faecal microbiota transplantation (FMT), in mitigating neuropsychiatric and neurodegenerative conditions

When co-administered with SERT, memory and anxiolytic effects improved significantly compared to DEX-treated group administered with SERT, and these suggest that SILY could also be beneficial as an adjunct with SERT in depression management