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GCL comprises a catalytic (GCLC) and a modifier (GCLM) subunit, and its activity can be readily inhibited with DL-buthionine-sulphoximine (BSO) [13]
This is why Walshs approach emphasizes balancing methylationnot with folates, which can worsen symptoms in undermethylated individualsbut with nutrients that rebuild the methyl cycle naturally
This is why most experienced researchers gravitate toward 10mg/mL for their maintenance phase and may use 5mg/mL during initiation for added precision at the 1mg and 2mg doses
Serious risks & who should not take it Serious but less common risks include pancreatitis, gallbladder problems, kidney injury from dehydration, and low blood sugar (especially if combined with insulin or sulfonylureas)
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