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Spironolactone has demonstrated weak P-gp inhibitory activity in preclinical models
PMID: 30214426
Additionally, there is a risk of choledocholithiasis (stones migrating into the common bile duct), which can cause jaundice, pancreatitis, or ascending cholangitis, all of which are serious medical emergencies
GPX4 genetic silencing in vitro The lentiviral plasmids, either non-targeted vector (pLKO.1-shNT) or pLKO.1-shGPX4 plasmid DNAs (Sigma-Aldrich) were transfected along with packaging and envelop plasmids psPAX2 and pMD2.G into HEK293T cells
A., Ryan, C
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