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Featuring 94% sequence homology to endogenous human GLP-1, this 31-amino acid polypeptide incorporates two critical structural modifications: an aminoisobutyric acid (Aib) substitution at position 8 to prevent degradation by the DPP-4 enzyme, and the attachment of a C18 fatty diacid via a hydrophilic spacer

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A further signaling cascade implicated includes cAMP binding and activation of Rap1A and guanine nucleotide exchange factors (GEFs) [31,32,33,34]

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Safety, side effects, and considerations Early animal studies show BPC 157 safety data as encouraging