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Additionally, another downstream substrate of the insulin-induced PI3K/AKT pathway is serine phosphorylation at the 133rd position of CREB, which increases mitochondrial membrane potential, hexokinase activity, NAD(P)H redox state, and intracellular ATP levels (28)
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For example, administration of prebiotics, such as inulin and oligofructose, inhibits feed intake via enhancing the synthesis of glucagon-like peptide (GLP-1) and peptide YY (PYY), as well as inhibiting the ghrelin production in obese and healthy adults [54, 55]
Appendix A: Dosage information on proton pump inhibitors NICE guideline CG184
Nitric oxide release in turn supports vasodilation, which has been proposed as a contributor to the perfusion-related findings in tissue-injury models
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