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77,78,79 For example, Golodirsen, an ASO drug targeting the human Duchenne muscular dystrophy (DMD) gene, was introduced in the USA in 2019 by Sarepta Therapeutics to treat DMD patients with confirmed mutations amenable to exon 53 skipping
When cells undergo ferroptosis, cell mitochondria become smaller, membrane density increases, and the number of cristae decreases, accompanied by increased cytoplasmic lipid peroxidation and increased levels of reactive oxygen species (ROS) [16, 18, 21]
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Characterization of the acyl-adenylate linked metabolite of mefenamic Acid
Molecules, 27 (12), 3737
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