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Targeting EAT modulation via GLP-1RAs represents a compelling strategy to disrupt the obesitydiabetesAF axis, although challenges remain in elucidating precise molecular mechanisms, standardizing EAT assessment, understanding response heterogeneity, and defining the clinical role of specific GLP-1RAs within AF management algorithms

TB-500 also suppresses the NF-kB inflammatory pathway systemically, not just locally

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Key takeaway: The initial phase is about tuning in with your body