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Contrave, approved in 2014, combines naltrexone and bupropion through a different mechanism than newer agents like Mounjaro, which activates both GLP-1 and GIP receptors to produce stronger metabolic effects

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Case presentation Four male patients were diagnosed with NAION during semaglutide treatment, with treatment durations of less than one year in three cases

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For a medication class, 20 years is a short window for understanding long-term safety and effects