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The company estimates that more than 50% of patients taking GLP-1 drugs stop because of costs, while more than a third do so because of side effects
The difference becomes more pronounced with higher-dose injectable semaglutide: Wegovy (2.4 mg weekly) demonstrated mean weight loss of approximately 15% of body weight in the STEP clinical trial program for obesity management, substantially exceeding outcomes typically seen with oral semaglutide at diabetes-approved doses
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The oncogenic effect of insulin could be due to the overexpression of insulin receptor by cancer cells, but also to its ability to interact with the IGF1 receptor, especially at supraphysiologic doses (Sciacca et al., 2010)
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