The objective of this review is to provide a comprehensive and structured synthesis of the immunopathogenesis of HT, integrating established knowledge with emerging research areas including oxidative stress, gut microbiota, and epigenetic modifications, while also summarizing current clinical, diagnostic, and therapeutic perspectives (Fig
Mitochondria-derived peptide MOTS-c: Effects and mechanisms related to stress, metabolism and aging
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Inflammation and Cytokine Modulation: ERK1/2 pathway activation, reduction of inflammatory cytokines (TNF-, IL-6), AKT phosphorylation enhancement, KRAS expression modulation
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