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In sepsis-induced AKI models, PKM2 inhibition attenuates the activation of NLR family pyrin domain containing 3 (NLRP3) and absent in melanoma 2 (AIM2) inflammasomes, decreases the release of IL-1, IL-18, and HMGB1 by macrophages, and ultimately improves survival outcomes (Xie et al., 2016)

This result suggested they might be recognizing nontarget features, such as the GGS linker between lysozyme and RNAP, rather than authentic substrate residues

Compounded peptides are not subject to the same manufacturing standards as FDA-approved drugs

These results established a crucial connection between the serine protease function of hepsin and protection against APAP-induced hepatotoxicity

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In vivo studies have demonstrated that dietary deprivation of methionine and cystine decreases the growth of glioma cells in mice (115)