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The Area Postrema: How Your Brain Senses the Medicine GLP-1 medications also work by activating GLP-1 receptors, which play a role in managing your appetite and food cravings

Highlights GLP-1 medicines reduce fat and liver mass more rapidly than skeletal muscle (SKM) Running performance is maintained or improved in mice on GLP-1 medicine GLP-1 medicine modifies the SKM proteome despite similar weight loss as calorie restriction Patients on GLP-1 medicine slightly reduce SKM mass but largely maintain strength Summary The large decrease in body weight with glucagon-like peptide-1 (GLP-1) medicines raises concern about a loss of lean body mass (LBM) and skeletal muscle

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These degradation byproducts are unknown variables introduced into your experiment