Matthew J
The condition must be confirmed by genetic testing demonstrating variants in POMC, PCSK1, or LEPR genes that are interpreted as pathogenic, likely pathogenic, or of a variant of uncertain significance (VUS)
Typically this type of decision would be made by those same career staff members
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The PLS-5 provides a comprehensive assessment of children's receptive and expressive vocabulary and is administrated by a trained assessor ( The developmental status of each participant was measured using the Mullen Scales of Early Learning (MSEL) administered by a trained assessor and the Vineland Adaptive Behavior Scale, 2nd edition (VABS-II) completed by parent interview
Cai J, Chen Y, Seth S, Furukawa S, Compans RW, Jones DP