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Visible weight-loss results usually appear around weeks 48, and the strongest changes show up between 812 weeks as the dose increases

Despite the successful trial, 10.6% of participants discontinued the 36mg and 12mg treatment due to adverse effects, compared to 4.6% in the placebo group

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However, stopping too early may lead to regaining weight, so providers usually recommend ongoing use alongside lifestyle changes

JCI Insight 5

Healthy dietary and lifestyle practices should remain the foundation for obesity treatment and management, with medications such as GLP-1 receptor agonists used as adjuncts. Such practices not only help prevent excess weight gain but can also lead to numerous health benefits that go beyond weight control, he concludes