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But it turns out, there actually is an abundant ready supply of animal pancreases that happen to be just lying around in the American heartland and just about every human food production center in the world

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These physiologically low-toxicity ligands, upon AhR activation, tend to induce transcriptional programs that maintain mucosal homeostasis and immune tolerance, including stabilization of Treg phenotypes, enhancement of the IL-22-mediated barrier protection axis, and suppression of excessive Th17-driven inflammation, thereby functionally biasing AhR signaling toward immune protection in this context (Zelante et al., 2013