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In terms of PAD severity, the geometric mean ABI was 0.79 (coefficient of variation [CV]: 0.3) in females and 0.74 (CV: 0.4) in males (SMD = 0.17) (Table 1)
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Following HMGB1 inhibition or 5-HT7R knockout, the downstream Nrf2/xCT/GPX4 signaling pathways was upregulated, resulting in alleviated depressive-like behaviors (Du et al., 2025)
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