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Public Plan Spending Context The Globe and Mail reports that public plans spent $794 million on Ozempic in 2024, and if plans cover Mounjaro, it could cost them an estimated $1.97 billion over three years, about $820 million more than the plans currently spend on comparable drugs over a similar period
Similarly, the author tends to choose incretins over thiazolidinediones (TZDs) in many patients because of the potential adverse effects of TZDs, including weight gain, peripheral edema, and increased risk of congestive heart failure [3]
It is a credible hypothesis, not an established therapy
Clinical development challenges including the identification of biomarkers to forecast patient responses to certain receptor combinations
Dipeptidyl peptidase-4 (DPP-4), in particular, is an enzyme that degrades GLP-1
That matters because trial participants are screened and monitored differently from people using medicines in routine care
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