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This maintains more stable blood levels throughout the 24-hour period and may reduce GI side effects compared to a single larger dose

To understand whether the GLP-1MK-801 conjugate activates distinct neural circuitries, we used light-sheet microscopy and cFOS immunohistochemistry to obtain quantitative 3D whole-brain activity signatures in response to GLP-1MK-801 and semaglutide dosing (Fig