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The resulting catastrophic energy deficit is a primary physiological driver of post-exertional malaise (PEM) or 'crashes,' where even minor, everyday activities trigger a disproportionate and prolonged exacerbation of profound fatigue, muscle weakness, and cognitive impairment

Amsterdam, Elsevier, pp 109118 Arduini A, Gorbunov N, Arrigoni-Martelli E, Dottori S, Molajoni F, Russo F, Federici G

But the line running through the whole article is simpler than any of that

The clinical manifestations of ALS usually appear between 5060 years of age, suggesting that neurons die through cumulative damage to normal cellular processes

Glutathione supports the healthy development of cells and helps protect against oxidative stress by neutralizing free radicals

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