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A: Peptide therapy typically has a loading period of 3-6 months for full effects

These SPP1 + macrophages drive fibrosis by secreting their encoded protein, osteopontin (OPN), which interacts with CD44/integrin receptors on stromal progenitor cells, such as fibro-adipogenic progenitors (FAPs), thereby promoting their differentiation into matrix-producing fibroblasts (185)

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