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The cAMP-PKA pathways regulate the activity and expression of the cAMP-response element modulator (CREM) protein family in CD4+ T-cells, linked to effector cytokine expression in psoriasis/PsA and other autoimmune diseases, such as SLE

Leal AD, Qin R, Atherton PJ, et al., Alliance for Clinical Trials in Oncology

This shared pathway activation enhances signal transduction efficiency and potency, amplifying regulatory effects on cellular metabolism and physiological functions

Nausea hits 28% of users, vomiting 17%, diarrhea 24%, and constipation 21%

Based on a previous systematic review and meta-analysis by He et al

Zipursky JS et al