Not everybody can take GLP-1
Understanding Genetic Predispositions in GLP-1 Peptide Pathways Genetic variants in GLP-1 receptor (GLP1R), GIP receptor (GIPR), FTO, and melanocortin-4 receptor (MC4R) genes may influence how individual metabolic pathways respond to peptide-based therapies
The company will continue to cover these drugs for diabetes treatment and may offer large employers the option to keep weight-loss coverage
However, several GLP-1 medications can be kept at room temperature for limited periods before first use, according to their specific product information: Wegovy (semaglutide) : Unopened pens may be kept at temperatures up to 30C for up to 28 days before use Trulicity (dulaglutide) : Unopened pens may be kept at temperatures up to 30C for up to 14 days before use Ozempic, Victoza, Saxenda : Check the specific product information for allowable room temperature storage before first use When storing unopened pens in the refrigerator: Keep the pen in its original carton to protect it from light exposure, which can degrade the active ingredient Store towards the back of the refrigerator rather than in the door, where temperature fluctuations are more common Never place the pen in the freezer compartment or allow it to freeze

It has shown significant promise as an effective intervention against type 2 diabetes (T2D) and excessive body weight, resulting in the United States Food and Drug Administration (FDA) approving its use against both conditions in May 2022 for T2D and November 2023 for obesity
How PlexusDx Supports a More Personalized Approach PlexusDx's Precision Peptide Genetic Test analyzes variants in GIPR and FTO, and MC4R to help contextualize your peptide-pathway predispositions