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In one small study, acetyl-L-carnitine improved memory in older people and in Alzheimer patients

54 Cancer stem cell (CSC)-like traits, characterized by robust DNA repair capacity and increased expression of drug efflux pumps, are tightly linked to chemoresistant phenotypes

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Nutrients 15(18):3952 Nassini R, Materazzi S, Benemei S, Geppetti P (2014) The TRPA1 channel in migraine mechanism and treatment

Examples Canagliflozin (Invokana) Dosage Initial: 100 mg once daily before the first meal of the day Maximum: 300 mg once daily Dapagliflozin (Farxiga) Dosage Initial: 510 mg once daily Maximum: 10 mg once daily Empagliflozin (Jardiance) Dosage Initial: 10 mg once daily Maximum: 25 mg once daily Possible side effects include: Urinary tract infections Genital fungal (mycotic) infections (ie, Candida infection) Hypovolemia (low extracellular fluid) and hypotension (low blood pressure) Acute kidney injury, possibly as a result of volume depletion (limited and contradictory evidence) Diabetic ketoacidosis (rare) Osteoporosis and bone fractures Dipeptidyl peptidase-IV (DPP-4) inhibitors Primary mechanism(s) of action Enhance incretin signaling via inhibition of the enzyme dipeptidyl peptidase-IV (DPP-4), which breaks down GLP-1 and glucose-dependent insulinotropic polypeptide (GIP)