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In lean subjects, NNMT activity in adipose tissue tends to be low

References: Mark Heffernan, Roger J

As a critical molecule in cellular energy metabolism and DNA repair, insufficient NAD+ directly triggers a series of metabolic abnormalities, including impaired mitochondrial function, reduced energy metabolism efficiency, and weakened DNA repair capacity

Also got comments about gaining tone in my muscles because of my metabolism working better

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This could theoretically affect DNA methylation, gene expression, and other processes dependent on methylation