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Research-Based Cycle Protocols Short-Term Assessment (4-8 Weeks): An initial 4-8 week cycle allows evaluation of individual response, tolerance assessment, and metabolic changes without extended commitment

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Meanwhile, hypoxia activates the HIF-1/PDK4 axis, which inhibits PDH activity and elevates mitochondrial membrane potential(MMP), suppressing the TCA cycle while enhancing glycolysis and lactate production, ultimately driving VSMC cell cycle progression and proliferation [86]

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