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Retatrutide produces approximately 30-50% more frequent GI side effects than tirzepatide at comparable efficacy doses

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GH-class effects at higher doses: increased hunger, mild joint aches (water retention), transient insulin resistance monitor fasting glucose

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The glucagon-like peptide 1 (GLP-1) analogue exendin-4 reduces alcohol intake and attenuates cue-induced reinstatement of alcohol seeking in rats