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TLR signaling and nicotinamide adenine dinucleotide (NAD) + levels regulate NLRC5 expression and ROS production, enabling NLRC5 to sense NAD + depletion and PAMP/heme or heme/cytokine signals, form a PANoptosome with NLRP12, and drive pyroptosis, apoptosis, and necroptosis (PANoptosis) and inflammation [173]

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