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Moreover, E2 potentiates GLP-1s effects on food intake in female rats (57) and reward (58) in both sexes, but to a greater extent in females compared to males, suggesting a synergistic relationship between these hormones at least in young adult rats
This reduces the risk of rebound weight gain and increases confidence in maintaining results
Lastly, ongoing research into the molecular pathways involved in DN will be crucial for identifying new therapeutic targets
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