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What side effects should prompt me to stop taking semaglutide immediately
[16] [19] Subsequent analysis of SUSTAIN-6 data revealed that the increased risk was concentrated among patients who entered the trial with pre-existing diabetic retinopathy and experienced rapid improvements in glycemic control
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Contact your GP if you experience: Persistent or severe nausea and vomiting that prevents you from eating or drinking adequately, as this may lead to dehydration Symptoms of acid reflux that do not improve with lifestyle modifications or over-the-counter treatments within one to two weeks Difficulty swallowing, persistent vomiting, or unintentional weight loss , which may suggest more serious oesophageal or gastric problems Signs of dehydration including reduced urination, dizziness, dry mouth, or feeling faint New or worsening visual symptoms , as rapid improvement in blood glucose can worsen diabetic retinopathy in some patients Right upper abdominal pain, fever, or yellowing of the skin/eyes , which could indicate gallbladder problems (cholelithiasis or cholecystitis) Seek immediate medical attention if you develop: Severe, persistent abdominal pain with or without vomiting, which could indicate acute pancreatitisif this occurs, stop taking Rybelsus and seek urgent medical care Acute chest pain or pressure , especially if accompanied by breathlessness, sweating, or pain radiating to the jaw or armcall 999, even if you suspect it might be severe heartburn Signs of an allergic reaction such as swelling of the face, lips, tongue, or throat, difficulty breathing, or severe skin rash Symptoms of hypoglycaemia (low blood sugar) if taking Rybelsus with insulin or sulfonylureasthese include trembling, sweating, confusion, rapid heartbeat, or loss of consciousness Your GP can assess whether your symptoms are related to Rybelsus, require dose adjustment, or indicate a separate condition needing investigation
The combination produced 24.2% weight loss at the 12mg dose in Phase 2 trials, the highest reported for any GLP-1 class medication so far
This study suggests oral semaglutide may help reduce heavy and harmful drinking, even in people who are not trying to quit alcohol entirely, said Joseph Schacht, PhD, associate professor at the CU Anschutz School of Medicine in the Department of Psychiatry
