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In supplementation, the goal is primarily to promote more efficient passage and more consistent release, without claiming therapeutic targeting

To systematically evaluate the pathways driving this sensitivity, we performed continuous gene set enrichment analysis (GSEA) ranking all mapped genes by their Pearson correlation coefficient ( R ) between basal expression (log 2 (TPM + 1)) and the PRISM log 2 (fold de-enrichment) across the 470 matched cell lines (note that 5 cell lines were not listed on HPA and were therefore not included

"It's good to have more options for patients with obesity," says Melanie Jay, MD, assistant professor of medicine at the NYU Grossman School of Medicine

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