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Similarly, in a diabetic rat model induced by a high-fat diet and streptozotocin (STZ) injection [54, 55], liraglutide was shown to mitigate the hyperglycemia-induced decline in RGC-5 cell viability and improve the structural integrity and organization of the GCL [56]

However, taking very high doses at once can sometimes cause digestive upset

Glucagon-like peptide-1 (GLP-1) agonist therapies are increasingly being used for type 2 diabetes and obesity, but evidence now shows they also reduce inflammation across multiple organs through mechanisms related and unrelated to weight-loss-driven metabolic improvements

2007) (Figure 16)

Tirzepatide escalation began at 2.5mg/week for 4 weeks, escalating by 2.5mg increments every 4 weeks to the target dose