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(2) Sikiric P, Seiwerth S, Rucman R, Kolenc D, et al
Eur J Heart Fail 22:14951503 Seferovi PM, Fragasso G, Petrie M, Mullens W, Ferrari R, Thum T, Bauersachs J, Anker SD, Ray R, avuolu Y, Polovina M, Metra M, Ambrosio G, Prasad K, Seferovi J, Jhund PS, Dattilo G, elutkiene J, Piepoli M, Moura B, Chioncel O, Ben Gal T, Heymans S, Jaarsma T, Hill L, Lopatin Y, Lyon AR, Ponikowski P, Lainak M, Jankowska E, Mueller C, Cosentino F, Lund LH, Filippatos GS, Ruschitzka F, Coats AJS, Rosano GMC (2020) Heart Failure Association of the European Society of Cardiology update on sodium-glucose co-transporter 2 inhibitors in heart failure
In addition, weight loss is a consistent finding in clinical trials investigating GLP-1RAs ( Reduction of hepatic and adipose tissue insulin resistance An improved insulin sensitivity is expected after chronic treatment with GLP-RAs mainly due to marked bodyweight reductions
Starting Dose and Titration Schedule Retatrutide phase 2 used a structured titration: Weeks 1 to 4: 2 mg subcutaneous once weekly Weeks 5 to 8: 4 mg once weekly Weeks 9 to 12: 8 mg once weekly Week 13 onward: 12 mg once weekly (maximum dose) Gastrointestinal adverse events drove dose reductions in 15.7% of participants receiving 12 mg in the phase 2 trial
Stretch marks arent a health risk and are not usually an indication of poor health