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144,145 Increased intestinal permeability has been shown to be an issue in individuals with IBS-D and has been associated with visceral hypersensitivity
The increasing complexity of neurological and neurodegenerative disorders, coupled with the paradigm shift toward precision medicine, has exposed the limitations of traditional clinical trial designs
This led to semaglutide's chemical synthesis and early laboratory testing throughout the 2000s
The developing brain undergoes rapid iron-dependent processes, including neurogenesis, neuronal migration, synaptogenesis, myelination, and maturation of dopaminergic pathways, during which even marginal iron deficiency may induce persistent neurodevelopmental alterations (Felt & Tran 2025
10.1371/journal.pone.0042785 278 ten BrinkeL
Basic Neurochemistry NCBI Bookshelf
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