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The reduction of Ub is a signal of improved cell homeostasis, which implies a reduced protein degradation caused by the stress response
Huang Y, Wang H, Tang G, Zhou Z, Zhang X, Liu Y, Yan G, Wang J, Hu G, Xiao J, Yan W, Cao Y
18, 2014), R
High levels of oxidative stress may contribute to ALS onset, increasing motoneurons death, and heavy metals may be a cause for the increase of ROS
However, the association was also shown for acetyl-carnitine, an isoform of l-carnitine, which adds confidence to the findings
ROBINS-I A Tool Assessing Risk Bias Non-randomised Studies Interventions 355, i4919
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