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The Phase 2 obesity trial used a slow, supervised dose escalation precisely because nausea, vomiting, and dehydration are most severe during dose increases

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Moreover, the Summary of Product Characteristics on the Electronic Medicines Compendium states that Therapeutic experience in patients 75 years of age is limited

One side effect that gets people asking questions: dysesthesia TRIUMPH4 reporting mentions dysesthesia (odd, uncomfortable sensations like tingling/burning) and says it was generally mild and infrequently led to discontinuation

Herbal teas such as ginger, chamomile, and peppermint may help relieve nausea, though this has not been specifically proven for GLP-1-related nausea

Research suggests that the sleep hormone melatonin also boosts glutathione status, this by stimulating production of the antioxidant enzyme glutathione peroxidase