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Thats something to keep in mind when taking GLP-1, since the medication can cause muscle loss

Multiple clinical and personal factors determine how long an individual might take GLP-1 medications

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We hope that this work will help us understand why these receptors work differently to each other, why they have different strengths at triggering the release of insulin and glucagon, and how changes in the genes that code for them modify the way they work in specific people.

Romo L, Earl S, Mueller KA, Obiol M