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The rationale is simple: 8mg provides nearly as much weight loss as 12mg (22.8% vs 24.2%) with a better side effect profile

Daily ICV injections of OXM over 7 days led to food intake reduction and increased weight loss compared with saline treated controls (29)

Given the number of trials, we want to highlight that this meta-regression had limited power

This tapering process helps minimize the risk of rapid weight regain and gives you time to strengthen lifestyle habits

These medications improve appetite control, delay gastric emptying, and optimize metabolic function, creating potential benefits for sleep quality