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For diabetes, you must try metformin plus one other oral agent for 90 days each before GLP-1 approval

doi: 10.1001/archneurol.2010.225 71 QiLKeLLiuXLiaoLKeSLiuXet al

These benefits extend even to non-diabetic individuals, suggesting mechanisms beyond glucose lowering

Seizure Disorders Stimulants may lower the seizure threshold, meaning they can make it easier for a seizure to occur in people with epilepsy or other seizure disorders

If a dose is missed, administer within 4 days

The NHS and NICE emphasise that weight management should be undertaken with professional guidance, particularly when prescription medicines are involved